Further information: Digoxin toxicity The occurrence of adverse drug reactions is common, owing to its narrow therapeutic index the margin between effectiveness and toxicity. Gynaecomastia enlargement of breast tissue is mentioned in many textbooks as a side effect, thought to be due to the estrogen -like steroid moiety of the digoxin molecule,  but when systematically sought, the evidence for this is equivocal as of [update]. This inhibition causes an increase in intracellular sodium levels, resulting in decreased activity of the sodium-calcium exchanger , which normally imports three extracellular sodium ions into the cell and transports one intracellular calcium ion out of the cell. The reversal of this exchanger causes an increase in the intracellular calcium concentration that is available to the contractile proteins. Increased intracellular calcium lengthens phase 4 and phase 0 of the cardiac action potential , which leads to a decrease in heart rate.
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International Journal of Clinical Pharmacology and Therapeutics. Views Read Edit View history. Determination of digitoxin and other glycosides and genins in Digitalis purpurea. From Wikipedia, the free encyclopedia. Cardenolides in surface-cultures of cotyledones and leaves of Digitalis purpurea. Investigations on the biosynthesis of digitalis d glycosides enzymatic glycosylation of digitoxin by a particulate enzyme fraction of digitalis purpurea d.
Biosynthesis of digitoxin in Digitalis purpurea The first description of the use of foxglove dates back to Ceskoslovenska Farmacie 2 Studies in the genus Digitalis.
It is a phytosteroid and is similar in structure and effects to digoxin though the effects are longer-lasting. Quantitative determination of digitoxin and gitoxin in digitalis purpurea.
Industrial lyophilization tests of medicinal plants vi purple digitalis d digitalis purpurea d digitoxin glucoside. Chemistry of natural compounds: Alcoholic glycoside Cardiac glycoside Bufadienolide Cardenolide Cyanogenic glycoside Glycosylamine Phenolic glycoside Anthraquinone glycoside Coumarin glycoside Flavonoid glycoside Saponin Steviol glycoside Thioglycoside.
There was a problem providing the content you requested Arenobufagin Bufotalin Cinobufagin Marinobufagin. Unlike digoxin which is eliminated from the body via oof kidneysit is eliminated via the liver, so could be used in patients with poor or erratic kidney function.
Studies on the production of Digitalis cardenolides by plant tissue culture. Ouabain g-Strophanthin k-Strophanthin Cymarin. Digitoxin and related cardenolides display potent anticancer activity against a range of human cancer cell lines in vitro but the clinical use of digitoxin to treat cancer has been restricted by its narrow therapeutic index. Quantitative determination of digitoxin and gitoxin in the leaves of Digitalis purpurea.
Journal of Pharmacy and Pharmacology 8 Comparative investigation of the biology of Digitalis lanata, Digitalis ambigua, Digitalis purpurea and Digitalis purpurea grafted population. However, it is now rarely used in current Western medical practice.
Transl9 5 Annales Pharmaceutiques Francaises 25 Biosynthesis of digitoxin in digitalis purpurea. This page was last edited on 20 Septemberat The colorimetric estimation of digitoxin and of preparations of Digitalis purpurea. Enzymatic glucosylation of digitoxin by particle enzyme fractions of Digitalis purpurea.
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